Modelling Developmental Regulatory Networks

Abstract. This paper introduces a model for simulating regulatory networks that is capable of reproducing spatial and temporal expression patterns in developmental processes. The model is a generalization of the standard connectionist model used for modelling genetic interactions, where the terms for the regulation of gene products and the diffusion term have been separated. This model can be coupled with biomechanical models of cell aggregates and used to study the formation of spatial and temporal expression patterns of gene products during development in cellular systems.

• Type: Conference
• Year: 2003
• Where: ICCS
• Authors: Tommy Krul, Jaap A. Kaandorp, Joke G. Blom
• Keywords: Gene Products, ICCS 2003, Standard Connectionist Model, Temporal Expression Patterns