Monte Carlo simulation of latanoprost induced iris darkening

We show that it is possible to construct numerical models of eye colour from first principles. Our initial model assumes that the important optical interactions occur only in the anterior border of the iris. Experimentally measured values for the size and number density of melanin granules in the anterior border in human irises are utilised. The scattering and absorption properties of these granules are obtained as a function of size by using Mie scattering theory, and these values are stored as a look-up table at the start of the simulations. These tables are then employed in our Monte Carlo simulations in order to determine the reflectance as a function of wavelength of light. We employ CIE colour theory in order to produce an RGB value from these reflectance spectra. In particular, we investigate an undesirable side effect of iris darkening and colour change following topical administration of glaucoma drugs (specifically Latanoprost). We show that small changes in the size-distribu...

• Type: Journal
• Year: 2007
• Where: CMPB
• Authors: K. P. B. Cracknell, Damian J. J. Farnell, I. Grierson
• Keywords: Anterior Border, CMPB 2007, CMPB 2008, Initial Model, Melanin Granules