An information-theoretic analysis of a multi-keyhole channel, which includes a number of statistically independent keyholes with possibly different correlation matrices, is given. When the number of keyholes or/and the number of Tx/Rx antennas is large, there is an equivalent Rayleigh-fading channel such that the outage capacities of both channels are asymptotically equal. In the case of a large number of antennas and for a broad class of fading distributions, the instantaneous capacity is shown to be asymptotically Gaussian in distribution, and compact, closed-form expressions for the mean and variance are given. Motivated by the asymptotic analysis, a simple, full-ordering scalar measure of spatial correlation and power imbalance in MIMO channels is introduced, which quantifies the negative impact of these two factors on the outage capacity in a simple and well-tractable way. It does not require the eigenvalue decomposition, and has the full-ordering property. The size-asymptotic res...