The stream ciphers Py, Pypy and Py6 were designed by Biham and Seberry for the ECRYPT-eSTREAM project in 2005. The ciphers were promoted to the ‘Focus’ ciphers of the Phase II of the eSTREAM project. However, due to some cryptanalytic results on the ciphers, strengthened versions of the ciphers, namely TPy, TPypy and TPy6 were built. So far there exists no attacks on TPy6. In this paper, we find hitherto unknown weaknesses in the keystream generation algorithms of the Py6 and of its stronger variant TPy6. Exploiting these weaknesses, a large number of distinguishing attacks are mounted on the ciphers, the best of which works with 2224.6 data and comparable time. In the second part, we present two new ciphers derived from the TPy6, namely TPy6-A and TPy6-B, whose performances are 2.65 cycles/byte and 4.4 cycles/byte on Pentium III. As a result, to the best of our knowledge, on Pentium platforms TPy6-A becomes the fastest stream cipher in the literature. Based on our security analys...