Public key cryptography has been invented to overcome some key management problems in open networks. Although nearly all aspects of public key cryptography rely on the existence of trapdoor one-way functions, only a very few candidates of this primitive have been observed yet. In this paper, we introduce a new trapdoor one-way permutation based on the hardness of factoring integers of p2 q-type. We also propose a variant of this function with a different domain that provides some advantages for practical applications. To confirm this statement, we develop a simple hybrid encryption scheme based on our proposed trapdoor permutation that is CCA-secure in the random oracle model.