On a novel coalescent model for genome-wide evolution of Copy Number Variations

: Since we are limited in our knowledge of human demographic history and variations of recombination and mutation rates, large-scale computer simulation is a necessary tool in genetics. Here, we propose and computationally simulate a model of evolution for unique and segmentally duplicated regions of human genome. Since such segmentally duplicated regions show a complex behaviour of copy number changes, our model is hoped to lead to a better understanding of the evolutionary developments of CNVs, algorithms for associations studies with CNV markers, and finally, for characterising parameters for stochastic diffusion models, describing asymptotic behaviour of evolutionary processes.

• Type: Journal
• Year: 2010
• Where: IJDMB
• Authors: Antonina Mitrofanova, Bhubaneswar (Bud) Mishra
• Keywords: Copy Number Changes, Human Demographic History, IJDMB 2010, Stochastic Diffusion Models