Ontologies enable explicit expression of collective concepts and support Machine-to-Machine (M2M) interactions at the semantic level. Ontologies expressed in a standard language, such as the Web Ontology Language (OWL) and exposed on a network offer the potential for unprecedented interoperability solutions since they are semantically rich, computer interpretable and inherently extensible. In this paper, we describe how we applied ontologies in OWL for rapid enterprise integration of heterogeneous data sources. We found that once a robust foundational domain ontology is established, it is easy and quick to integrate new data sources and therefore rapidly provide new system capabilities.