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CCE
2008

Optimal delivery of chemotherapeutic agents in cancer

13 years 11 months ago
Optimal delivery of chemotherapeutic agents in cancer
In this paper, derivation of the optimal chemotherapy schedule is formulated and solved as a dynamic optimization problem. For this purpose two models representing the tumour growth kinetics are considered. The dynamic optimization problem for the first model, which is cell cycle non-specific, takes into account multiple time characteristics, drug resistance and toxicity. The discontinuity in the model is formulated by introducing integer variables. For the second model, which is cell cycle specific, the tumour growth is modelled via two compartments: proliferating and resting compartment.
Pinky Dua, Vivek Dua, Efstratios N. Pistikopoulos
Added 09 Dec 2010
Updated 09 Dec 2010
Type Journal
Year 2008
Where CCE
Authors Pinky Dua, Vivek Dua, Efstratios N. Pistikopoulos
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