Biogas plants are reliable sources of energy based on renewable materials including organic waste. There is a high demand from industry to run these plants efficiently, which leads to a highly complex simulation and optimization problem. A comparison of several algorithms from computational intelligence to solve this problem is presented in this study. The sequential parameter optimization was used to determine improved parameter settings for these algorithms in an automated manner. We demonstrate that genetic algorithm and particle swarm optimization based approaches were outperformed by differential evolution and covariance matrix adaptation evolution strategy. Compared to previously presented results, our approach required only one tenth of the number of function evaluations.