Polyploids, genome halving and phylogeny

Autopolyploidization and allopolyploidization events multiply the number of chromosomes and genomic content. Genome rearrangement phylogenetics requires that all genomes analyzed have the same set of orthologs, so that it is not possible to include diploid and polyploid genomes in the same phylogeny. We propose a framework for solving this difficulty by integrating the rearrangement median and genome halving algorithms. Though the framework is general, some problems remain open. We solve the prototytpical case of a tree with one tetraploid and two diploid genomes, and apply our method to study the evolution of cereals and of yeast.

• Type: Conference
• Year: 2007
• Where: ISMB
• Authors: David Sankoff, Chunfang Zheng, Qian Zhu
• Keywords: Computational Biology, Genome Halving Algorithms, Genome Rearrangement Phylogenetics, ISMB 2007, Rearrangement Median