PRINTS and PRINTS-S shed light on protein ancestry

The PRINTS database houses a collection of protein fingerprints. These may be used to make family and tentative functional assignments for uncharacterised sequences. The September 2001 release (version 32.0) includes 1600 fingerprints, encoding 10 000 motifs, covering a range of globular and membrane proteins, modular polypeptides and so on. In addition to its continued steady growth, we report here its use as a source of annotation in the InterPro resource, and the use of its relational cousin, PRINTS-S, to model relationships between families, including those beyond the reach of conventional sequence analysis approaches. The database is accessible for BLAST, fingerprint and text searches at http://www.bioinf.man.ac.uk/ dbbrowser/PRINTS/.

• Type: Journal
• Year: 2002
• Where: NAR
• Authors: Terri K. Attwood, Martin J. Blythe, Darren R. Flower, Anna Gaulton, J. E. Mabey, Neil Maudling, L. McGregor, Alex Mitchell, G. Moulton, K. Paine, Philip Scordis
• Keywords: Continued Steady Growth, NAR 2002, Protein Fingerprints, Tentative Functional Assignments