A multiresolution technique for biomedical image interpolation is presented in this paper. It is an extension of the work on Directional Coherence Interpolation (DCI) [15] ? a novel gray-level image interpolation method that interpolates the missing image data along the smoothed Maximum Coherence Directions (MCDs). We propose to apply a pyramidal search strategy for MCD estimation. This coarse-to-fine scheme requires less computation time by starting with the reduced amount of data and propagating searching results to finer resolutions. In addition, it also improves robustness compared with our previous single resolution DCI.