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RECOMB
2008
Springer

Reconstructing the Evolutionary History of Complex Human Gene Clusters

15 years 4 days ago
Reconstructing the Evolutionary History of Complex Human Gene Clusters
Abstract. Clusters of genes that evolved from single progenitors via repeated segmental duplications present significant challenges to the generation of a truly complete human genome sequence. Such clusters can confound both accurate sequence assembly and downstream computational analysis, yet they represent a hotbed of functional innovation, making them of extreme interest. We have developed an algorithm for reconstructing the evolutionary history of gene clusters using only human genomic sequence data. This method allows the tempo of large-scale evolutionary events in human gene clusters to be estimated, which in turn will facilitate primate comparative sequencing studies that will aim to reconstruct their evolutionary history more fully.
Adam C. Siepel, Eric D. Green, Giltae Song, Tom&aa
Added 03 Dec 2009
Updated 03 Dec 2009
Type Conference
Year 2008
Where RECOMB
Authors Adam C. Siepel, Eric D. Green, Giltae Song, Tomás Vinar, Webb Miller, Yu Zhang
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