—This paper introduces several new guiding ideologies in “the Principle of Computer Organization” course reform, based on the purpose of application-oriented personnel training, namely teaching according to the students aptitude, focusing on students’ capacity-building, emphasizing both theories and experiments. In the practice of curriculum teaching, we focus on the training and enhancing of students self-learning ability through group collaborative learning and examination reform. Meanwhile, we try to motivate the students to study with process management methods and course websites, thus the teaching effectiveness maybe significantly improved. Keywords- Teaching quality; individualized; examination reform; group collaborative learning