A method for processing images prior to normalized mutual information based registration and an enhancement of the registration measure are presented. The method relies on k-means clustering of the intensity distribution and a gray-value remapping of spatially unconnected segments of similar intensity. Registration experiments using binary images from the MPEG-7 dataset and retinal images show our preprocessing to cause a significant reduction of the number of misregistrations without loss of accuracy or an increase in optimization steps.
Zeger F. Knops, J. B. Antoine Maintz, Max A. Vierg