Video streaming demands high data rates and hard delay constraints, and it raises several challenges on today’s packet-based and best-effort internet. In this paper, we propose an efficient multiple-description coding (MDC) technique based on video frame sub-sampling and cubicspline interpolation to provide spatial diversity, such that no additional buffering delay or storage is required. The frame dropping rate due to packet loss and drifting error under the multi-path streaming environment is analyzed in this paper.