We propose a region-of-interest (ROI) coding framework based on leaky prediction (LP) for robustly transporting H.264 video over error-prone network. The LP-based ROI coding can remove error drift caused by the destruction in the decoded background from the proposed system, with guaranteed ROI quality throughout. Experimental results show that this scheme enables the decoder to reconstruct the ROI with better quality and the global video frame with improved quality even if the background bitstream cannot be correctly received or completely lost.