—This paper proposes a selective data pruning-based compression scheme to improve the rate-distortion relation of compressed images and video sequences. The original frames are pruned to a smaller size before compression. After decoding, they are interpolated back to their original size by an edge-directed interpolation method. The data pruning phase is optimized to obtain the minimal distortion in the interpolation phase. Furthermore, a novel high-order interpolation is proposed to adapt the interpolation to several edge directions in the current frame. This high-order filtering uses more surrounding pixels in the frame than the fourth-order edge-directed method and it is more robust. The algorithm is also considered for multiframe-based interpolation by using spatio-temporally surrounding pixels coming from the previous frame. Simulation results are shown for both image interpolation and coding applications to validate the effectiveness of the proposed methods.