Computers today are not only the calculation tools - they are directly (inter)acting in the physical world which itself may be conceived of as the universal computer (Zuse, Fredkin, Wolfram, Chaitin, Lloyd). In expanding its from abstract logical symbol manipulation to physical embedded and networked devices, computing goes beyond Church-Turing limit (Copeland, Siegelman, Burgin, Schachter). Computational processes are distributed, reactive, interactive, agent-based and concurrent. The main criterion of success of computation is not its termination, but the adequacy of its response, its speed, generality and flexibility; adaptability, and tolerance to noise, error, faults, and damage. Interactive computing is a generalization of Turing computing, and it calls for new conceptualizations (Goldin, Wegner). In the info-computationalist framework, with computation seen as information processing, natural computation appears as the most suitable paradigm of computation and information semanti...