With the advent of Web services and orchestration specifications like BPEL it is possible to define workflows on an Internet-scale. In the health-care domain highly structured and well defined workflows have been specified in standard documents. To reduce the complexity of creating Web service orchestration specifications, we provide a model-driven design approach, consisting of manual and automatic transformations. Security and transaction requirements are covered additionally. The resulting Web services can be bound dynamically at run-time. Therefore, we gain the flexibility to integrate processes that are already established with specific business protocols. Parts of this approach should be applicable to other domains, too.