- As scientific achievements in the area of Healthcare have increased during the last decade, inevitably there has been an increase of treatment quality. One of the challenges to be confronted is the personalization of treatment. The personalization requires the continuous reconfiguration of the treatment schemes since the clinical status of each patient and circumstances inside a healthcare organization constantly change. In this paper we present a prototype that provides an IT solution concerning the real-time adaptation of healthcare processes. The software comprises a healthcare process execution engine assisted by a semantic info-structure for reconfiguring the pathways. The semantic info-structure utilizes an ontology enclosing the required knowledge and a semantic rule-set. During the execution of clinical pathways, the system reasons over the rules, the knowledge and information, and reconfigures the next steps of the treatment. The results of the rule-set execution may generat...