The importance of and the fast changes in the CIO's role in organizations are widely recognized. So is the need for CIOs to acquire the appropriate set of knowledge and managerial skills to lead the organization's effort in effectively using Information Technology. This study is based on an extensive survey of the literature addressing the desirable features of modern CIOs and the Information system area main activities. This study aims at evaluate (1) the impact of such features on the management performance of the IS department main activities and (2) their consequent impact on overall company performance. To empirically test these two relationships, 111 CEOs of companies located in Northern Italy were interviewed. The analysis of collected data provides some insights on the desirable features for modern CIOs, which in turn can be useful for CIO recruiting and professional development, and highlight the importance to properly manage the IS subfunctions in order to improve ...