Abstract. The aim of this paper is to provide insight in the important role simulation technologies can play in the context of effective business process-oriented learning. The gap between business processes and HR carrying out concrete tasks could be bridged by integrating knowledge management and learning needs with respect to business processes. First, the importance between business processes, learning and simulations is illustrated. Second, simulations and their impact for company efficiency is outlined. Third, the benefits of the PROLIX e-simulation are described according to specific requirements out of a business process perspective. A company case study is also presented. The conclusion is that decision support for management under specific performance conditions and the learning environment itself are key elements that contemporary e-simulations bring together for the benefit of work performance and effectiveness as well as efficiency of companies.