siVirus: web-based antiviral siRNA design software for highly divergent viral sequences

siVirus (http://siVirus.RNAi.jp/) is a web-based online software system that provides efficient short interfering RNA (siRNA) design for antiviral RNA interference (RNAi). siVirus searches for functional, off-target minimized siRNAs targeting highly conserved regions of divergent viral sequences. These siRNAs are expected to resist viral mutational escape, since their highly conserved targets likely contain structurally/functionally constrained elements. siVirus will be a useful tool for designing optimal siRNAs targeting highly divergent pathogens, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), influenza virus and SARS coronavirus, all of which pose enormous threats to global human health.

• Type: Journal
• Year: 2006
• Where: NAR
• Authors: Yuki Naito, Kumiko Ui-Tei, Toru Nishikawa, Yutaka Takebe, Kaoru Saigo
• Keywords: Antiviral Rna Interference, Divergent Viral Sequences, NAR 2006, Viral Mutational Escape