SMART 5: domains in the context of genomes and networks

The Simple Modular Architecture Research Tool 10 (SMART) is an online resource (http://smart.embl. de/) used for protein domain identification and the analysis of protein domain architectures. Many new features were implemented to make SMART more accessible to scientists from different fields. The 15 new `Genomic' mode in SMART makes it easy to analyze domain architectures in completely sequenced genomes. Domain annotation has been updated with a detailedtaxonomic breakdown and a prediction of the catalytic activity for 50 SMART domains is now 20 available, based on the presence of essential amino acids. Furthermore, intrinsically disordered protein regions can be identified and displayed. The network context is now displayed in the results page for more than 350 000 proteins, enabling easy analyses of 25 domain interactions.

• Type: Journal
• Year: 2006
• Where: NAR
• Authors: Ivica Letunic, Richard R. Copley, Birgit Pils, Stefan Pinkert, Jörg Schultz, Peer Bork
• Keywords: NAR 2006, Proteins, Simple Modular Architecture, SMART