In this paper some research questions which potentially lie within the purview of the new discipline of Computational Transportation Science are presented. Some of these questions are no doubt old and jaded and some may rightly reside in a different research field (or be seen as engineering) but viable solutions to all of the issues presented are of vital importance to the efficacy of future transportation systems. Categories and Subject Descriptors J.m [Transportation]: Computational Transportation Science— communications, control, human factors General Terms Proposed research directions