Statistics of Optical Coherence Tomography Data From Human Retina

—Optical coherence tomography (OCT) has recently become one of the primary methods for noninvasive probing of the human retina. The pseudoimage formed by OCT (the so-called B-scan) varies probabilistically across pixels due to complexities in the measurement technique. Hence, sensitive automatic procedures of diagnosis using OCT may exploit statistical analysis of the spatial distribution of reflectance. In this paper, we perform a statistical study of retinal OCT data. We find that the stretched exponential probability density function can model well the distribution of intensities in OCT pseudoimages. Moreover, we show a small, but significant correlation between neighbor pixels when measuring OCT intensities with pixels of about 5 m. We then develop a simple joint probability model for the OCT data consistent with known retinal features. This model fits well the stretched exponential distribution of intensities and their spatial correlation. In normal retinas, fit parameters ...

• Type: Journal
• Year: 2010
• Where: TMI
• Authors: Norberto M. Grzywacz, Joaquín de Juan, Claudia Ferrone, Daniela Giannini, David Huang, Giorgio Koch, Valentina Russo, Ou Tan, Carlo Bruni
• Keywords: OCT Data, Retinal Oct Data, Stretched Exponential, TMI 2010