STRING 7 - recent developments in the integration and prediction of protein interactions

Information on protein–protein interactions is still mostly limited to a small number of model organisms, and originates from a wide variety of experimental and computational techniques. The database and online resource STRING generalizes access to protein interaction data, by integrating known and predicted interactions from a variety of sources. The underlying infrastructure includes a consistent body of completely sequenced genomes and exhaustive orthology classifications, based on which interaction evidence is transferred between organisms. Although primarily developed for protein interaction analysis, the resource has also been successfully applied to comparative genomics, phylogenetics and network studies, which are all facilitated by programmatic access to the database backend and the availability of compact download files. As of release 7, STRING has almost doubled to 373 distinct organisms, and contains more

• Type: Journal
• Year: 2007
• Where: NAR
• Authors: Christian von Mering, Lars Juhl Jensen, Michael Kuhn 0004, Samuel Chaffron, Tobias Doerks, Beate Krüger, Berend Snel, Peer Bork
• Keywords: Exhaustive Orthology Classifications, NAR 2007, Protein Interaction Analysis, Protein–protein Interactions