This paper presents TNC-UTM, a holistic solution to secure enterprise networks from gateway to endpoints. Just as its name suggested, the TNC-UTM solution combines two popular techniques TNC and UTM together by defining an interface between them that integrates their security capacity to provide efficiently network access control and security protection for enterprise network. Not only TNC-UTM provides the features of TNC and UTM, but also it achieves stronger security and higher performance by introducing intelligent configuration decisions and RBAC mechanism. Experiment demonstrated the superior advantages of the TNC-UTM solution.