Recently, due to its wide applications, subgraph search has attracted a lot of attention from database and data mining community. Sub-graph search is defined as follows: given a query graph Q, we report all data graphs containing Q in the database. However, there is little work about sub-graph search in a single large graph, which has been used in many applications, such as biological network and social network. In this paper, we address top-k sub-graph matching query problem, which is defined as follows: given a query graph Q, we locate top-k matchings of Q in a large data graph G according to a score function. The score function is defined as the sum of the pairwise similarity between a vertex in Q and its matching vertex in G. Specifically, we first design a balanced tree (that is G-Tree) to index the large data graph. Then, based on G-Tree, we propose an efficient query algorithm (that is Ranked Matching algorithm). Our extensive experiment results show that, due to efficie...