Toward the dynamic interactome: it's about time

Dynamic molecular interactions play a central role in regulating the functioning of cells and organisms.The availability of experimentally determined large-scale cellular networks, along with other high-throughput experimental data sets that provide snapshots of biological systems at different times and conditions, is increasingly helpful in elucidating interaction dynamics. Here we review the beginnings of a new subfield within computational biology, one focused on the global inference and analysis of the dynamic interactome. This burgeoning research area, which entails a shift from static to dynamic network analysis, promises to be a major step forward in our ability to model and reason about cellular function and behavior.

• Type: Journal
• Year: 2010
• Where: BIB
• Authors: Teresa M. Przytycka, Mona Singh, Donna K. Slonim
• Keywords: BIB 2010, Central Role, Dynamic Molecular Interactions, Large-scale Cellular Networks