Translog, a web browser for studying the expression divergence of homologous genes

Background: Increasing amount of data from comparative genomics, and newly developed technologies producing accurate gene expression data facilitate the study of the expression divergence of homologous genes. Previous studies have individually highlighted factors that contribute to the expression divergence of duplicate genes, e.g. promoter changes, exon structure heterogeneity, asymmetric histone modifications and genomic neighborhood conservation. However, there is a lack of a tool to integrate multiple factors and visualize their variety among homologous genes in a straightforward way. Results: We introduce Translog (a web-based tool for Transcriptome comparison of homologous genes) that assists in the comparison of homologous genes by displaying the loci in three different views: promoter view for studying the sharing/turnover of transcription initiations, exon structure for displaying the exon-intron structure changes, and genomic neighborhood to show the macro-synteny conservati...

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Xianjun Dong, Altuna Akalin, Yogita Sharma, Boris Lenhard
• Keywords: BMCBI 2010, Expression Divergence, Genomic Neighborhood, Homologous Genes