In [13], Erd˝os et al. defined the local chromatic number of a graph as the minimum number of colors that must appear within distance 1 of a vertex. For any ∆ ≥ 2, there are graphs with arbitrarily large chromatic number that can be colored so that (i) no vertex neighborhood contains more than ∆ different colors (bounded local colorability), and (ii) adjacent vertices from two color classes induce a complete bipartite graph (biclique coloring). We investigate the weighted vertex cover problem in graphs when a locally bounded coloring is given. This generalizes the vertex cover problem in bounded degree graphs to a class of graphs with arbitrarily large chromatic number. Assuming the Unique Game Conjecture, we provide a tight characterization. We prove that it is UGC-hard to improve the approximation ratio of 2 − 2/(∆ + 1) if the given local coloring is not a biclique coloring. A matching upper bound is also provided. Vice versa, when properties (i) and (ii) hold, we presen...