Background: A growing demand for tools to assist the building and analysis of biological networks exists in systems biology. We argue that the use of a formal approach is relevant...
Background: This article addresses the problem of interoperation of heterogeneous bioinformatics databases. Results: We introduce BioWarehouse, an open source toolkit for construc...
Thomas J. Lee, Yannick Pouliot, Valerie Wagner, Pr...
Increasingly, biology researchers and medical practitioners are using computational tools to model and analyze dynamic systems across scales from the macro to the cellular to the ...
Nicholas F. Polys, Doug A. Bowman, Chris North, Re...
— Systems biologists are often faced with competing models for a given experimental system. Unfortunately, performing experiments can be time-consuming and expensive. Therefore, ...
Background: The modeling of dynamic systems requires estimating kinetic parameters from experimentally measured time-courses. Conventional global optimization methods used for par...