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BMCBI
2005
152views more  BMCBI 2005»
13 years 9 months ago
Improved profile HMM performance by assessment of critical algorithmic features in SAM and HMMER
Background: Profile hidden Markov model (HMM) techniques are among the most powerful methods for protein homology detection. Yet, the critical features for successful modelling ar...
Markus Wistrand, Erik L. L. Sonnhammer
ECML
2006
Springer
14 years 21 days ago
Unsupervised Multiple-Instance Learning for Functional Profiling of Genomic Data
Multiple-instance learning (MIL) is a popular concept among the AI community to support supervised learning applications in situations where only incomplete knowledge is available....
Corneliu Henegar, Karine Clément, Jean-Dani...
NN
2007
Springer
267views Neural Networks» more  NN 2007»
13 years 8 months ago
Modeling of gene regulatory networks with hybrid differential evolution and particle swarm optimization
In the last decade, recurrent neural networks (RNNs) have attracted more efforts in inferring genetic regulatory networks (GRNs), using time series gene expression data from micro...
Rui Xu, Ganesh K. Venayagamoorthy, Donald C. Wunsc...
BMCBI
2010
178views more  BMCBI 2010»
13 years 9 months ago
Selecting high-dimensional mixed graphical models using minimal AIC or BIC forests
Background: Chow and Liu showed that the maximum likelihood tree for multivariate discrete distributions may be found using a maximum weight spanning tree algorithm, for example K...
David Edwards, Gabriel C. G. de Abreu, Rodrigo Lab...
BMCBI
2005
169views more  BMCBI 2005»
13 years 9 months ago
MAPPER: a search engine for the computational identification of putative transcription factor binding sites in multiple genomes
Background: Cis-regulatory modules are combinations of regulatory elements occurring in close proximity to each other that control the spatial and temporal expression of genes. Th...
Voichita D. Marinescu, Isaac S. Kohane, Alberto Ri...