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BMCBI
2011
13 years 1 months ago
2011
Background: Estimation of allele frequency is of fundamental importance in population genetic analyses and in association mapping. In most studies using next-generation sequencing...
BMCBI
2011
13 years 1 months ago
2011
Background: Statistical methods for ranking differentially expressed genes (DEGs) from gene expression data should be evaluated with regard to high sensitivity, specificity, and r...
BMCBI
2011
13 years 1 months ago
2011
Background: The Smith-Waterman algorithm for local sequence alignment is more sensitive than heuristic methods for database searching, but also more time-consuming. The fastest ap...
BMCBI
2011
13 years 1 months ago
2011
Background: A central question in cancer biology is what changes cause a healthy cell to form a tumor. Gene expression data could provide insight into this question, but it is dif...
BMCBI
2011
13 years 1 months ago
2011
Background: Results of phylogenetic analysis are often visualized as phylogenetic trees. Such a tree can typically only include up to a few hundred sequences. When more than a few...