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» A New Similarity Measure among Protein Sequences
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BMCBI
2005
130views more  BMCBI 2005»
13 years 9 months ago
Some statistical properties of regulatory DNA sequences, and their use in predicting regulatory regions in the Drosophila genome
Background: This paper addresses the problem of recognising DNA cis-regulatory modules which are located far from genes. Experimental procedures for this are slow and costly, and ...
Irina I. Abnizova, Rene te Boekhorst, Klaudia Walt...
BMCBI
2010
136views more  BMCBI 2010»
13 years 9 months ago
Protein structure analysis of mutations causing inheritable diseases. An e-Science approach with life scientist friendly interfa
Background: Many newly detected point mutations are located in protein-coding regions of the human genome. Knowledge of their effects on the protein's 3D structure provides i...
Hanka Venselaar, Tim A. H. te Beek, Remko K. P. Ku...
IPPS
2007
IEEE
14 years 3 months ago
High Performance Database Searching with HMMer on FPGAs
1 Profile Hidden Markov Models (profile HMMs) are used as a popular bioinformatics tool for sensitive database searching, e.g. a set of not annotated protein sequences is compared...
Timothy F. Oliver, Leow Yuan Yeow, Bertil Schmidt
BIBM
2009
IEEE
206views Bioinformatics» more  BIBM 2009»
14 years 4 months ago
ChemAlign: Biologically Relevant Multiple Sequence Alignment Using Physicochemical Properties
—We present a new algorithm, ChemAlign, that uses physicochemical properties and secondary structure elements to create biologically relevant multiple sequence alignments (MSAs)....
Hyrum Carroll, Mark J. Clement, Quinn Snell, David...
BMCBI
2010
147views more  BMCBI 2010»
13 years 9 months ago
Learning biological network using mutual information and conditional independence
Background: Biological networks offer us a new way to investigate the interactions among different components and address the biological system as a whole. In this paper, a revers...
Dong-Chul Kim, Xiaoyu Wang, Chin-Rang Yang, Jean G...