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» A New Similarity Measure among Protein Sequences
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BMCBI
2010
113views more  BMCBI 2010»
13 years 9 months ago
Statistical method on nonrandom clustering with application to somatic mutations in cancer
Background: Human cancer is caused by the accumulation of tumor-specific mutations in oncogenes and tumor suppressors that confer a selective growth advantage to cells. As a conse...
Jingjing Ye, Adam Pavlícek, Elizabeth A. Lu...
ECEASST
2010
13 years 6 months ago
Self Organized Swarms for cluster preserving Projections of high-dimensional Data
: A new approach for topographic mapping, called Swarm-Organized Projection (SOP) is presented. SOP has been inspired by swarm intelligence methods for clustering and is similar to...
Alfred Ultsch, Lutz Herrmann
RECOMB
2008
Springer
14 years 9 months ago
BayCis: A Bayesian Hierarchical HMM for Cis-Regulatory Module Decoding in Metazoan Genomes
The transcriptional regulatory sequences in metazoan genomes often consist of multiple cis-regulatory modules (CRMs). Each CRM contains locally enriched occurrences of binding site...
Tien-ho Lin, Pradipta Ray, Geir Kjetil Sandve, Sel...
BMCBI
2006
120views more  BMCBI 2006»
13 years 9 months ago
Optimizing amino acid substitution matrices with a local alignment kernel
Background: Detecting remote homologies by direct comparison of protein sequences remains a challenging task. We had previously developed a similarity score between sequences, cal...
Hiroto Saigo, Jean-Philippe Vert, Tatsuya Akutsu
TCBB
2011
13 years 4 months ago
Data Mining on DNA Sequences of Hepatitis B Virus
: Extraction of meaningful information from large experimental datasets is a key element of bioinformatics research. One of the challenges is to identify genomic markers in Hepatit...
Kwong-Sak Leung, Kin-Hong Lee, Jin Feng Wang, Eddi...