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» A Physicochemical Model for Analyzing DNA Sequences
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BMCBI
2010
101views more  BMCBI 2010»
13 years 6 months ago
Detection of copy number variation from array intensity and sequencing read depth using a stepwise Bayesian model
Background: Copy number variants (CNVs) have been demonstrated to occur at a high frequency and are now widely believed to make a significant contribution to the phenotypic variat...
Zhengdong D. Zhang, Mark B. Gerstein
BMCBI
2010
141views more  BMCBI 2010»
13 years 6 months ago
Computing and visually analyzing mutual information in molecular co-evolution
Background: Selective pressure in molecular evolution leads to uneven distributions of amino acids and nucleotides. In fact one observes correlations among such constituents due t...
Sebastian Bremm, Tobias Schreck, Patrick Boba, Ste...
ICDM
2002
IEEE
173views Data Mining» more  ICDM 2002»
13 years 11 months ago
Mining Genes in DNA Using GeneScout
In this paper, we present a new system, called GeneScout, for predicting gene structures in vertebrate genomic DNA. The system contains specially designed hidden Markov models (HM...
Michael M. Yin, Jason Tsong-Li Wang
BMCBI
2010
105views more  BMCBI 2010»
13 years 6 months ago
Comparison of PGH2 binding site in prostaglandin synthases
Background: Prostaglandin H2 (PGH2) is a common precursor for the synthesis of five different Prostanoids via specific Prostanoid Synthases. The binding of this substrate with the...
Padmapriya Paragi-Vedanthi, Mukesh Doble
BMCBI
2010
144views more  BMCBI 2010»
13 years 6 months ago
Graph-based clustering and characterization of repetitive sequences in next-generation sequencing data
Background: The investigation of plant genome structure and evolution requires comprehensive characterization of repetitive sequences that make up the majority of higher plant nuc...
Petr Novák, Pavel Neumann, Jirí Maca...