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» A Physicochemical Model for Analyzing DNA Sequences
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BIBM
2010
IEEE
151views Bioinformatics» more  BIBM 2010»
13 years 4 months ago
Probabilistic topic modeling for genomic data interpretation
Recently, the concept of a species containing both core and distributed genes, known as the supra- or pangenome theory, has been introduced. In this paper, we aim to develop a new ...
Xin Chen, Xiaohua Hu, Xiajiong Shen, Gail Rosen
BMCBI
2006
102views more  BMCBI 2006»
13 years 6 months ago
UVPAR: fast detection of functional shifts in duplicate genes
Background: The imprint of natural selection on gene sequences is often difficult to detect. A plethora of methods have been devised to detect genetic changes due to selective pro...
Vicente Arnau, Miguel Gallach, J. Ignasi Lucas, Ig...
ICPP
2009
IEEE
14 years 1 months ago
Load Balance in the Phylogenetic Likelihood Kernel
—Recent advances in DNA sequencing techniques have led to an unprecedented accumulation and availability of molecular sequence data that needs to be analyzed. This data explosion...
Alexandros Stamatakis, Michael Ott
BMCBI
2008
132views more  BMCBI 2008»
13 years 6 months ago
Mixture models for analysis of melting temperature data
Background: In addition to their use in detecting undesired real-time PCR products, melting temperatures are useful for detecting variations in the desired target sequences. Metho...
Christoffer Nellåker, Fredrik Uhrzander, Joa...
BMCBI
2008
110views more  BMCBI 2008»
13 years 6 months ago
Methylation Linear Discriminant Analysis (MLDA) for identifying differentially methylated CpG islands
Background: Hypermethylation of promoter CpG islands is strongly correlated to transcriptional gene silencing and epigenetic maintenance of the silenced state. As well as its role...
Wei Dai, Jens M. Teodoridis, Janet Graham, Constan...