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BMCBI
2008
108views more  BMCBI 2008»
15 years 4 months ago
New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic backgroun
Background: Few genetic factors predisposing to the sporadic form of amyotrophic lateral sclerosis (ALS) have been identified, but the pathology itself seems to be a true multifac...
Silvana Penco, Massimo Buscema, Maria Cristina Pat...
BMCBI
2008
100views more  BMCBI 2008»
15 years 4 months ago
Hotspot Hunter: a computational system for large-scale screening and selection of candidate immunological hotspots in pathogen p
Background: T-cell epitopes that promiscuously bind to multiple alleles of a human leukocyte antigen (HLA) supertype are prime targets for development of vaccines and immunotherap...
Guanglan Zhang, Asif M. Khan, Kellathur N. Sriniva...
BMCBI
2006
175views more  BMCBI 2006»
15 years 4 months ago
Parameter estimation for stiff equations of biosystems using radial basis function networks
Background: The modeling of dynamic systems requires estimating kinetic parameters from experimentally measured time-courses. Conventional global optimization methods used for par...
Yoshiya Matsubara, Shinichi Kikuchi, Masahiro Sugi...
BMCBI
2006
129views more  BMCBI 2006»
15 years 4 months ago
Independent Component Analysis-motivated Approach to Classificatory Decomposition of Cortical Evoked Potentials
Background: Independent Component Analysis (ICA) proves to be useful in the analysis of neural activity, as it allows for identification of distinct sources of activity. Applied t...
Tomasz G. Smolinski, Roger Buchanan, Grzegorz M. B...
BMCBI
2006
143views more  BMCBI 2006»
15 years 4 months ago
Fast estimation of the difference between two PAM/JTT evolutionary distances in triplets of homologous sequences
Background: The estimation of the difference between two evolutionary distances within a triplet of homologs is a common operation that is used for example to determine which of t...
Christophe Dessimoz, Manuel Gil, Adrian Schneider,...