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ALMOB
2006
138views more  ALMOB 2006»
13 years 6 months ago
A combinatorial optimization approach for diverse motif finding applications
Background: Discovering approximately repeated patterns, or motifs, in biological sequences is an important and widely-studied problem in computational molecular biology. Most fre...
Elena Zaslavsky, Mona Singh
BMCBI
2006
203views more  BMCBI 2006»
13 years 6 months ago
Genome-wide prediction of transcriptional regulatory elements of human promoters using gene expression and promoter analysis dat
Background: A complete understanding of the regulatory mechanisms of gene expression is the next important issue of genomics. Many bioinformaticians have developed methods and alg...
Seon-Young Kim, YongSung Kim
IDA
2008
Springer
13 years 6 months ago
ExpertDiscovery system application for the hierarchical analysis of eukaryotic transcription regulatory regions based on DNA cod
We developed Relational Data Mining approach which allows to overcome essential limitations of the Data Mining and Knowledge Discovery techniques. In the paper the approach was im...
I. V. Khomicheva, Eugenii E. Vityaev, Elena A. Ana...
ICMLA
2008
13 years 8 months ago
Ensemble Machine Methods for DNA Binding
We introduce three ensemble machine learning methods for analysis of biological DNA binding by transcription factors (TFs). The goal is to identify both TF target genes and their ...
Yue Fan, Mark A. Kon, Charles DeLisi
GECCO
2007
Springer
258views Optimization» more  GECCO 2007»
13 years 10 months ago
TFBS identification by position- and consensus-led genetic algorithm with local filtering
Identification of Transcription Factor Binding Site (TFBS) motifs in multiple DNA upstream sequences is important in understanding the mechanism of gene regulation. This identific...
Tak-Ming Chan, Kwong-Sak Leung, Kin-Hong Lee