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» A polyhedral approach to RNA sequence structure alignment
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BMCBI
2005
122views more  BMCBI 2005»
13 years 8 months ago
ASPIC: a novel method to predict the exon-intron structure of a gene that is optimally compatible to a set of transcript sequenc
Background: Currently available methods to predict splice sites are mainly based on the independent and progressive alignment of transcript data (mostly ESTs) to the genomic seque...
Paola Bonizzoni, Raffaella Rizzi, Graziano Pesole
WABI
2010
Springer
128views Bioinformatics» more  WABI 2010»
13 years 7 months ago
Sparsification of RNA Structure Prediction Including Pseudoknots
Background: Although many RNA molecules contain pseudoknots, computational prediction of pseudoknotted RNA structure is still in its infancy due to high running time and space con...
Mathias Möhl, Raheleh Salari, Sebastian Will,...
BMCBI
2011
13 years 10 days ago
Structator: fast index-based search for RNA sequence-structure patterns
Background: The secondary structure of RNA molecules is intimately related to their function and often more conserved than the sequence. Hence, the important task of searching dat...
Fernando Meyer, Stefan Kurtz, Rolf Backofen, Sebas...
WG
2005
Springer
14 years 2 months ago
Fixed-Parameter Algorithms for Protein Similarity Search Under mRNA Structure Constraints
Abstract. In the context of protein engineering, we consider the problem of computing an mRNA sequence of maximal codon-wise similarity to a given mRNA (and consequently, to a give...
Guillaume Blin, Guillaume Fertin, Danny Hermelin, ...
GCB
2005
Springer
96views Biometrics» more  GCB 2005»
14 years 2 months ago
Thermodynamics of RNA-RNA Binding
We present an extension of the standard partition function approach to RNA secondary structures that computes the probabilities Pu[i, j] that a sequence interval [i, j] is unpaired...
Ulrike Mückstein, Hakim Tafer, Jörg Hack...