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BMCBI
2006
118views more  BMCBI 2006»
13 years 7 months ago
Statistical analysis of an RNA titration series evaluates microarray precision and sensitivity on a whole-array basis
Background: Concerns are often raised about the accuracy of microarray technologies and the degree of cross-platform agreement, but there are yet no methods which can unambiguousl...
Andrew J. Holloway, Alicia Oshlack, Dileepa S. Diy...
BMCBI
2005
103views more  BMCBI 2005»
13 years 7 months ago
Many accurate small-discriminatory feature subsets exist in microarray transcript data: biomarker discovery
Background: Molecular profiling generates abundance measurements for thousands of gene transcripts in biological samples such as normal and tumor tissues (data points). Given such...
Leslie Grate
JCB
2000
103views more  JCB 2000»
13 years 7 months ago
Testing for Differentially-Expressed Genes by Maximum-Likelihood Analysis of Microarray Data
Although two-color uorescent DNA microarrays are now standard equipment in many molecular biology laboratories, methods for identifying differentially expressed genes in microarra...
Trey Ideker, Vesteinn Thorsson, Andrew F. Siegel, ...
IJBRA
2007
89views more  IJBRA 2007»
13 years 7 months ago
Conservative adjustment of permutation p-values when the number of permutations is limited
The permutation procedure is widely used to assess the significance level (p-value) of a test statistic. This approach is asymptotically consistent. In genomics and proteomics st...
Yinglei Lai
MP
2006
103views more  MP 2006»
13 years 7 months ago
Assessing solution quality in stochastic programs
Determining if a solution is optimal or near optimal is fundamental in optimization theory, algorithms, and computation. For instance, Karush-Kuhn-Tucker conditions provide necessa...
Güzin Bayraksan, David P. Morton