Background: Protein sequence alignment is one of the basic tools in bioinformatics. Correct alignments are required for a range of tasks including the derivation of phylogenetic t...
Tomas Ohlson, Varun Aggarwal, Arne Elofsson, Rober...
Background: Since the publication of the first draft of the human genome in 2000, bioinformatic data have been accumulating at an overwhelming pace. Currently, more than 3 million...
Elijah Roberts, John Eargle, Dan Wright, Zaida Lut...
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
For discrete co-occurrence data like documents and words, calculating optimal projections and clustering are two different but related tasks. The goal of projection is to find a ...
Shipeng Yu, Kai Yu, Volker Tresp, Hans-Peter Krieg...
In spite of the popularity of probabilistic mixture models for latent structure discovery from data, mixture models do not have a natural mechanism for handling sparsity, where ea...