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BMCBI
2010
133views more  BMCBI 2010»
13 years 10 months ago
Predicting enzyme targets for cancer drugs by profiling human Metabolic reactions in NCI-60 cell lines
Background: Drugs can influence the whole metabolic system by targeting enzymes which catalyze metabolic reactions. The existence of interactions between drugs and metabolic react...
Limin Li, Xiaobo Zhou, Wai-Ki Ching, Ping Wang
BMCBI
2010
190views more  BMCBI 2010»
13 years 10 months ago
APIS: accurate prediction of hot spots in protein interfaces by combining protrusion index with solvent accessibility
Background: It is well known that most of the binding free energy of protein interaction is contributed by a few key hot spot residues. These residues are crucial for understandin...
Jun-Feng Xia, Xing-Ming Zhao, Jiangning Song, De-S...
RECOMB
2001
Springer
14 years 10 months ago
Towards predicting coiled-coil protein interactions
Protein-protein interactions play a central role in many cellular functions, and as whole-genome data accumulates, computational methods for predicting these interactions become i...
Mona Singh, Peter S. Kim
ICDM
2007
IEEE
121views Data Mining» more  ICDM 2007»
14 years 4 months ago
Finding Predictive Runs with LAPS
We present an extension to the Lasso [9] for binary classification problems with ordered attributes. Inspired by the Fused Lasso [8] and the Group Lasso [10, 4] models, we aim to...
Suhrid Balakrishnan, David Madigan
GECCO
2005
Springer
102views Optimization» more  GECCO 2005»
14 years 3 months ago
Evolutionary rule-based system for IPO underpricing prediction
Academic literature has documented for a long time the existence of important price gains in the first trading day of initial public offerings (IPOs). Most of the empirical analys...
David Quintana, Cristóbal Luque del Arco-Ca...