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BMCBI
2008
87views more  BMCBI 2008»
13 years 8 months ago
Identification of deleterious non-synonymous single nucleotide polymorphisms using sequence-derived information
Background: As the number of non-synonymous single nucleotide polymorphisms (nsSNPs), also known as single amino acid polymorphisms (SAPs), increases rapidly, computational method...
Jing Hu, Changhui Yan
BMCBI
2008
159views more  BMCBI 2008»
13 years 8 months ago
Estimation and testing for the effect of a genetic pathway on a disease outcome using logistic kernel machine regression via log
Background: Growing interest on biological pathways has called for new statistical methods for modeling and testing a genetic pathway effect on a health outcome. The fact that gen...
Dawei Liu, Debashis Ghosh, Xihong Lin
WSC
2000
13 years 10 months ago
Use of discrete event simulation to validate an agent based scheduling engine
This paper discusses the use of simulation in a new context. Most often QUEST is viewed as a stand-alone simulation tool to analyze and understand shop floor behavior. It has rare...
Shubhabrata Biswas, Sara Merchawi
BMCBI
2010
121views more  BMCBI 2010»
13 years 8 months ago
Knowledge-based annotation of small molecule binding sites in proteins
Background: The study of protein-small molecule interactions is vital for understanding protein function and for practical applications in drug discovery. To benefit from the rapi...
Ratna R. Thangudu, Manoj Tyagi, Benjamin A. Shoema...
BMCBI
2010
98views more  BMCBI 2010»
13 years 8 months ago
miRMaid: a unified programming interface for microRNA data resources
Background: MicroRNAs (miRNAs) are endogenous small RNAs that play a key role in post-transcriptional regulation of gene expression in animals and plants. The number of known miRN...
Anders Jacobsen, Anders Krogh, Sakari Kauppinen, M...