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BMCBI
2011
13 years 1 months ago
Sequential Interim Analyses of Survival Data in DNA Microarray Experiments
Background: Discovery of biomarkers that are correlated with therapy response and thus with survival is an important goal of medical research on severe diseases, e.g. cancer. Freq...
Andreas Leha, Tim Beißbarth, Klaus Jung
BMCBI
2005
93views more  BMCBI 2005»
13 years 7 months ago
Two-part permutation tests for DNA methylation and microarray data
Background: One important application of microarray experiments is to identify differentially expressed genes. Often, small and negative expression levels were clipped-off to be e...
Markus Neuhäuser, Tanja Boes, Karl-Heinz J&ou...
BMCBI
2008
78views more  BMCBI 2008»
13 years 7 months ago
Evaluation of time profile reconstruction from complex two-color microarray designs
Background: As an alternative to the frequently used "reference design" for two-channel microarrays, other designs have been proposed. These designs have been shown to b...
Ana C. Fierro, Raphael Thuret, Kristof Engelen, Gi...
ICDE
2003
IEEE
149views Database» more  ICDE 2003»
14 years 8 months ago
Indexing Weighted-Sequences in Large Databases
We present an index structure for managing weightedsequences in large databases. A weighted-sequence is defined as a two-dimensional structure where each element in the sequence i...
Haixun Wang, Chang-Shing Perng, Wei Fan, Sanghyun ...
BMCBI
2008
130views more  BMCBI 2008»
13 years 7 months ago
Function approximation approach to the inference of reduced NGnet models of genetic networks
Background: The inference of a genetic network is a problem in which mutual interactions among genes are deduced using time-series of gene expression patterns. While a number of m...
Shuhei Kimura, Katsuki Sonoda, Soichiro Yamane, Hi...