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BMCBI
2010
138views more  BMCBI 2010»
13 years 9 months ago
Amino acid classification based spectrum kernel fusion for protein subnuclear localization
Background: Prediction of protein localization in subnuclear organelles is more challenging than general protein subcelluar localization. There are only three computational models...
Suyu Mei, Wang Fei
ALGORITHMICA
2007
70views more  ALGORITHMICA 2007»
13 years 9 months ago
Sampling Conformation Space to Model Equilibrium Fluctuations in Proteins
This paper proposes the Protein Ensemble Method (PEM) to model equilibrium fluctuations in proteins where fragments of the protein polypeptide chain can move independently of one ...
Amarda Shehu, Cecilia Clementi, Lydia E. Kavraki
BMCBI
2008
114views more  BMCBI 2008»
13 years 9 months ago
Testing the Coulomb/Accessible Surface Area solvent model for protein stability, ligand binding, and protein design
Background: Protein structure prediction and computational protein design require efficient yet sufficiently accurate descriptions of aqueous solvent. We continue to evaluate the ...
Marcel Schmidt am Busch, Anne Lopes, Najette Amara...
ICCS
2004
Springer
14 years 3 months ago
Evolutionary Perspectives on Protein Thermodynamics
While modern evolutionary theory has emphasized the role of neutral evolution, protein biochemistry and biophysics has interpreted the properties of proteins as largely resulting f...
Richard A. Goldstein
BMCBI
2005
97views more  BMCBI 2005»
13 years 9 months ago
Comparative mapping of sequence-based and structure-based protein domains
Background: Protein domains have long been an ill-defined concept in biology. They are generally described as autonomous folding units with evolutionary and functional independenc...
Ya Zhang, John-Marc Chandonia, Chris H. Q. Ding, S...