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BMCBI
2004
174views more  BMCBI 2004»
13 years 9 months ago
Implications for domain fusion protein-protein interactions based on structural information
Background: Several in silico methods exist that were developed to predict protein interactions from the copious amount of genomic and proteomic data. One of these methods is Doma...
Jer-Ming Chia, Prasanna R. Kolatkar
BMCBI
2004
112views more  BMCBI 2004»
13 years 9 months ago
SPOC: A widely distributed domain associated with cancer, apoptosis and transcription
Background: The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) d...
Luis Sánchez-Pulido, Ana María Rojas...
BMCBI
2010
128views more  BMCBI 2010»
13 years 9 months ago
Conserved residue clusters at protein-protein interfaces and their use in binding site identification
Background: Biological evolution conserves protein residues that are important for structure and function. Both protein stability and function often require a certain degree of st...
Mainak Guharoy, Pinak Chakrabarti
JBCB
2010
138views more  JBCB 2010»
13 years 4 months ago
Hierarchical Classification of Gene Ontology Terms Using the Gostruct Method
Protein function prediction is an active area of research in bioinformatics. And yet, transfer of annotation on the basis of sequence or structural similarity remains widely used ...
Artem Sokolov, Asa Ben-Hur
SIBGRAPI
2008
IEEE
14 years 4 months ago
Structural Matching of 2D Electrophoresis Gels using Graph Models
2D electrophoresis is a well known method for protein separation which is extremely useful in the field of proteomics. Each spot in the image represents a protein accumulation an...
Alexandre Noma, Alvaro Pardo, Roberto Marcondes Ce...